uCoBATCH
Single-Cell Epigenomic Profiling
We developed uCoBATCH, utilizing a split-pool barcoding strategy for realizing ultra-high throughput single-cell epigenetic histone modification, transcription factor or chromatin accessibility.
uCoTECH
Single-cell joint detection of chromatin occupancy and transcriptome
We develop uCoTECH, a combinatorial barcoding method allowing high-throughput single-cell joint detection of chromatin occupancy and transcriptome.
uCoTargetX
Single-cell joint profiling of multiple epigenetic proteins and gene transcription.
We developed uCoTarget, utilizing a split-pool barcoding strategy for realizing ultra-high throughput single-cell joint profiling of multiple epigenetic proteins. Furthermore, we developed uCoTargetX, an expansion of uCoTarget to simultaneously measure transcriptome and multiple epigenome targets.(Xiong et al. Science Advances, 2024)
TACIT
TACIT and CoTACIT for histone modification profiling in single cells and lineage tracing
We developed TACIT and CoTACIT, single-cell chromatin indexing and tagmentation method that employs antibody-guided protein A–Tn5 transposition to barcode and map histone modifications genome-wide from as few as 20 cells.(Liu et al. Nature, 2025)
